Regulation of pancreatic islet cell survival and replication by γ-aminobutyric acid
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چکیده
منابع مشابه
γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells
γ-Aminobutyric acid (GABA) has been shown to inhibit apoptosis of rodent β-cells in vitro. In this study, we show that activation of GABAA receptors (GABAA-Rs) or GABAB-Rs significantly inhibits oxidative stress-related β-cell apoptosis and preserves pancreatic β-cells in streptozotocin-rendered hyperglycemic mice. Moreover, treatment with GABA, or a GABAA-R- or GABAB-R-specific agonist, inhibi...
متن کاملγ-Aminobutyric Acid Is Synthesized and Released by the Endothelium
number: 4338. 57. Grynberg A, Demaison L. Fatty acid oxidation in the heart. J Cardiovasc Pharmacol. 1996;28(suppl 1):S11–S17. 58. Thiriet M. Coronary artery disease and myocardial infarction. In: Diseases of the Cardiac Pump. Berlin: Springer; 2015:379–471.
متن کاملProduction of gaba (γ – Aminobutyric acid) by microorganisms: a review
GABA (γ-aminobutyric acid) is a four carbon non-protein amino acid that is widely distributed in plants, animals and microorganisms. As a metabolic product of plants and microorganisms produced by the decarboxylation of glutamic acid, GABA functions as an inhibitory neurotransmitter in the brain that directly affects the personality and the stress management. A wide range of traditional foods p...
متن کاملMaintaining the postharvest nutritional quality of peach fruits by γ-Aminobutyric acid . Morteza Soleimani Aghdam1*, Farhang Razavi2 and Fatemeh Karamneghad3
Fresh peaches are highly perishable and they deteriorate quickly during low temperature storage which results in losses in nutritional quality. To prevent these adverse effects, peach fruits were treated by dipping with γ-aminobutyric acid (GABA; 2, 4 and 6 mM) immediately after harvest and then stored at 1 °C for 7, 14, 21, and 28 days. Peach fruits treated with GABA exhibited higher flesh fir...
متن کاملSynthesis of γ - Aminobutyric Acid ( GABA ) by Lactic Acid Bacteria Isolated from Italian 1 Cheese Varieties 2 Running title : Lactic Acid Bacteria and γ - Aminobutyric Acid
* Corresponding author. Maria De Angelis, Dipartimento di Protezione delle Piante e 13 Microbiologia Applicata, Facoltà di Scienze Biotecnologiche di Bari, Via G. Amendola 165/a, 14 70126 Bari, Italy. Phone: ++ 39 080 5442948; Fax: ++ 39 080 5442911; E-mail: 15 [email protected] 16 17 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0601-8